Endocrine Abstracts

The role of ghrelin in the pathogenesis of acromegaly is doubtful. Ghrelin also regulates glucose and adipose tissue metabolism. It has not been demonstrated whether it contributes to the development of metabolic complications of acromegaly.Aim: The aim of the study was to assess: (1) whether serum concentrations of total and acyl ghrelin in patients with acromegaly differ in relation to coexisting metabolic complications (hypercholesterolemia, hyperinsu...

Introduction: Ghrelin is known to strongly stimulate growth hormone release from the pituitary. It was also found to be produced locally in hypothalamus and anterior pituitary and in different types of pituitary adenomas. It’s been suggested that ghrelin synthesized locally in hypothalamo–pituitary area or within pituitary tumours can be an important factor contributing to pituitary tumorogenesis.Aim: The aim of the study was the immunohistoche...

Ghrelin has been considered one of the factors that might contribute to the development of pituitary somatotropinoma.The aim of our study was to assess whether serum concentrations of ghrelin differ in patients with acromegaly treated with surgery or/and long-acting octreotide (LAO) and also to evaluate the presence of ghrelin mRNA in tissues of somatotroph adenomas. The appoval of Ethical Committee to perform the study was obtained.<p class="abstext...

Ghrelin is an endogenous ligand of the GH secretagogue receptor. The influence of ghrelin on different organs has been studied recently e.g. in the regulation of pituitary hormone release, regulation of energy homeostasis, glucose metabolism and insulin secretion, cell proliferation and reproductive function.The etiology of PCOS has not been firmly explained, althought several pathways have been implicated – the regulatory pathways of steroid hormon...